Multidisciplinary Journal of Science and Technology

PROBIOTIC BACTERIA AND THEIR IMPACT ON THE INTESTINAL MICROFLORA: MECHANISMS, CLINICAL APPLICATIONS, AND GLOBAL PERSPECTIVES

Almardanova Zulhumor

Assistant of the Department of Microbiology, Public Health, Hygiene and Management, TTA Termez Branch.

Ahmedova Saodat

Assistant of the Department of Microbiology, Public Health, Hygiene and Management, TTA Termez Branch.

Keywords: Probiotics,Intestinal microflora,Microbiome,Dysbiosis,Immunomodulation,Lactobacillus,Bifidobacterium,Synbiotic,Pos tbiotic,Antibiotic resistance,Gastrointestinal diseases,Metabolic syndrome,Intestinal barrier function,Microorganism interactions,Global health strategies

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Abstract

Probiotic bacteria play an important biological role in maintaining the balance of the human intestinal

microflora, supporting the immune system and preventing many chronic diseases. In recent years, the

complex interactions between the intestinal microbiome and the host organism have been studied in

depth, and probiotics are being effectively used not only in dysbiosis, but also in gastrointestinal

diseases, allergies, metabolic syndrome and even neurological disorders. This article covers the main

types of probiotic bacteria, their mechanisms of action on the intestinal microflora, clinical

applications and advantages in treatment protocols.

Also, the importance of probiotics in the context of antibiotic resistance, their use in pediatric and

adult practice, immunomodulatory effects, postbiotic and synbiotic concepts, as well as WHO, FAO

and global health strategies are analyzed. The results of the study confirm the clinical significance of

the rational use of probiotics, individual microbiome-based therapy and future innovative directions

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ISSN: 2582-4686 SJIF 2021-3.261,SJIF 2022-2.889,

2024-6.875 ResearchBib IF: 9.948 / 2024

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