PREVALENCE AND CLINICAL PHENOTYPES OF POLYCYSTIC OVARY SYNDROME IN ADOLESCENT GIRLS LIVING IN IODINE-DEFICIENT REGIONS

Keldieva Gulzirakhon

1st year master's student, Department of Endocrinology, Fergana Institute of Public Health

Karimova Mukima

Fergana Medical Institute of Public Health Head of the Department of Endocrinology, Hematology, and Phthisiology, PhD

Keywords: adolescent girls; polycystic ovary syndrome; prevalence; clinical phenotypes; hyperandrogenism.


Abstract

Polycystic ovary syndrome (PCOS) is one of the most common endocrine conditions affecting females of reproductive age, yet its recognition during adolescence remains methodologically challenging. Pubertal maturation is characterized by transient menstrual irregularity, acne, and multifollicular ovarian morphology—features that can overlap with PCOS and inflate prevalence estimates when adult criteria are applied without age-specific safeguards. Contemporary evidence demonstrates that adolescent PCOS prevalence varies substantially by diagnostic framework: meta-analytic data indicate higher estimates under the original Rotterdam criteria than under the stricter adolescent-oriented recommendations embedded within the 2023 International Evidence-Based Guideline.


References

1. Neven A.C.H., Louwers Y.V., Broekmans F.J.M. et al. Prevalence and accurate diagnosis of polycystic ovary syndrome in adolescents across world regions: a systematic review and meta-analysis // European Journal of Endocrinology. 2024. Vol. 191, No. 4. P. S15–S(по статье).

2. Teede H.J., Misso M.L., Costello M.F. et al. Recommendations from the 2023 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome // Journal of Clinical Endocrinology & Metabolism. 2023. Vol. 108, No. 10. P. 2447–2469.

3. Peña A.S., Witchel S.F., Hoeger K.M. et al. Adolescent-specific recommendations from the 2023 International Evidence-Based PCOS Guideline // BMC Medicine. 2025. (электронная публикация/ PDF).

4. World Health Organization. Iodine deficiency: Nutrition Landscape Information System (NLiS) [Электронный ресурс]. — Женева: WHO. — Режим доступа: who.int (дата обращения: 10.01.2026).

5. World Health Organization. Assessment of iodine deficiency disorders and monitoring their elimination: a guide for programme managers. 3rd ed. — Geneva: WHO, 2007. (электронный ресурс: страница издания). — Режим доступа: who.int (дата обращения: 10.01.2026).

6. Naz M.S.G., Tehrani F.R., Majd H.A. et al. The prevalence of polycystic ovary syndrome in adolescents: a systematic review and meta-analysis // International Journal of Reproductive BioMedicine. 2019. Vol. 17, No. 8. P. 533–542.