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ZENODO
Published
2026-02-14
Section
Articles
How to Cite
How to Cite
OPTIMIZING PREGRAVID PREPARATION: A MULTI-MODAL CLINICAL STRATEGY FOR MITIGATING GESTATIONAL COMPLICATIONS AND CONGENITAL FETAL ABNORMALITIES
Solieva Zilola
Master’s Candidate
Nosirova Feruza
Associate Professor
Keywords: Periconceptional Health, Fetal Programming, Congenital Malformations, Metabolic Priming, Obstetric Biostatistics.
Abstract
To evaluate the efficacy of an optimized, evidence-based pregravid preparation bundle in preventing adverse maternal and neonatal outcomes.
References
1. The 90-Day Rule: Pregravid preparation must encompass at least one full cycle of folliculogenesis (approx. 90 days) to impact the quality of the oocyte and the endometrial lining.
2. Personalized Screening: Mandatory screening for latent iron deficiency and MTHFR polymorphisms is recommended for women in high-risk categories.
3. Holistic Management: Clinicians should transition from a "supplementation-only" model to a "lifestyle-metabolic correction" model to ensure 100% preventive efficacy against preventable fetal defects.
8. References
1. Nosirova, F. J. (2023). Advanced Protocols in Obstetric Care. Tashkent Medical Press.
2. WHO (2024). Global Standards for Preconception Care. World Health Organization Report.
3. Barker, D. J. (2022). The Epigenetic Basis of Fetal Programming. Nature Reviews Endocrinology, 18(4), 210-225.
4. Smith, J., et al. (2023). Antioxidant Capacity and Early Pregnancy Loss. Journal of Perinatology.
5. Cochrane Database of Systematic Reviews (2024). Folate Supplementation for Preventing Birth Defects.
