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ZENODO
Published
2026-03-01
Section
Articles
How to Cite
How to Cite
CENTRAL NERVOUS SYSTEM TUMORS
Choriyev Abubakir
Xolmirzayev Muhammadjon
Keywords: Central nervous system tumors, diagnosis, molecular biomarkers, treatment strategies, prognosis
Abstract
Central nervous system tumors (CNS tumors) are heterogeneous neoplasms arising from the brain and spinal cord tissues, characterized by complex diagnostic, therapeutic, and prognostic features. The aim of this article is to identify the epidemiology, pathogenesis mechanisms, classification, diagnostic methods, and modern treatment strategies of CNS tumors, as well as to analyze factors affecting patient outcomes. The study was conducted based on a literature review, highlighting the most recent clinical and molecular research. The results show that molecular genetic biomarkers and advanced imaging techniques increase diagnostic accuracy in identifying and subtyping CNS tumors. Furthermore, combined strategies of surgery, radiotherapy, and targeted pharmacotherapy are effective in prolonging overall survival and improving symptom control. In conclusion, an integrated approach to CNS tumors is crucial for optimizing individualized treatment plans and improving clinical outcomes.
References
1. Central Nervous System Tumors: Clinical Guidelines and Management — RUSSCO recommendations for primary CNS tumor diagnosis and treatment.
2. Review of Pediatric CNS Tumors — MSD Professional Manual, clinical guidance on pediatric CNS tumors, diagnostics, and treatment approaches.
3. Various textbooks and lectures — Tumor classification, macro- and microstructure, clinical presentation.
4. Scientific articles and reviews (e.g., “Modern Perspectives on CNS Tumor Histology”) — Contemporary insights on histological features of tumors.
5. Tumors of the Central Nervous System (Springer, Vol. 13) — Comprehensive monograph on CNS tumor types, diagnostics, surgery, and metastases.
6. Primary Central Nervous System Tumors: Pathogenesis and Therapy (Springer) — Scientific monograph on pathogenesis and therapy of primary CNS tumors.
7. Central Nervous System Tumors: Diagnostic Pathology (Springer) — Latest diagnostic and pathological standards based on WHO 2021 classification.
8. WHO Classification of Tumours of the Central Nervous System (IARC/WHO Blue Book) — International standard classification and description of tumors.
