Multidisciplinary Journal of Science and Technology

MIGRAINE AND ITS TREATMENT METHODS

Choriyev Abubakir

Alimova Zebiniso

To'xtamurodova Dildora

Keywords: Migraine, headache, neurological disorder, diagnosis, triptans, prophylactic therapy, CGRP antagonists, neuromodulation.

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Abstract

Migraine is a common and disabling neurological disorder characterized by recurrent, severe headaches often accompanied by nausea, vomiting, photophobia, and phonophobia. It significantly impacts daily functioning, work productivity, and quality of life. This article reviews the pathophysiology, clinical features, diagnostic criteria, and current treatment strategies for migraine, including pharmacological and non-pharmacological approaches. Recent advances in targeted therapies, such as calcitonin gene-related peptide (CGRP) inhibitors, are also discussed. Understanding these mechanisms and treatments is crucial for effective management and improving patient outcomes.

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References

1. Goadsby PJ, Holland PR, Martins-Oliveira M, et al. Pathophysiology of migraine: a disorder of sensory processing. Physiol Rev. 2017;97(2):553–622.

2. Charles A. The pathophysiology of migraine: implications for clinical management. Lancet Neurol. 2018;17(2):174–182.

3. Edvinsson L. The CGRP pathway in migraine as a viable target for therapies. Headache. 2019;59 Suppl 2:33–47.

4. International Headache Society. The International Classification of Headache Disorders, 3rd edition (ICHD-3). Cephalalgia. 2018;38(1):1–211.

5. Silberstein SD. Preventive treatment of migraine. Neurol Clin. 2020;38(4):713–729.