CHANGES IN PLATELET HEMOSTASIS IN POST-COVID SYNDROME
Umurzakova Rokhila Zokirovna
##semicolon## post-COVID syndrome; PASC; platelet activation; thromboinflammation; platelet–leukocyte aggregates.
सार
Post-COVID syndrome (also referred to as post-acute sequelae of SARS-CoV-2 infection, PASC) is characterized by persistent, heterogeneous symptoms that may continue for months after the acute infection. A growing body of evidence suggests that dysregulated hemostasis—particularly sustained platelet activation and thromboinflammatory signaling—can persist beyond viral clearance and may contribute to microvascular dysfunction, impaired tissue perfusion, and fluctuating systemic inflammation.
##submission.citations##
1. Nicolai L., Kaiser R., Stark K. Thromboinflammation in long COVID—the elusive key to postinfection sequelae? // Journal of Thrombosis and Haemostasis. – 2023. – Vol. 21. – P. 2020–2031. – DOI: 10.1016/j.jtha.2023.04.039. PubMed
2. Luzak B. Complex Pattern of Platelet Activation/Reactivity After SARS-CoV-2 Infection // International Journal of Molecular Sciences. – 2024. – Vol. 26, No. 1. – Art. 49. – DOI: 10.3390/ijms26010049. PubMed+1
3. Ranucci M., Baryshnikova E., Anguissola M., et al. The Long Term Residual Effects of COVID-Associated Coagulopathy // International Journal of Molecular Sciences. – 2023. – Vol. 24, No. 6. – Art. 5514. – DOI: 10.3390/ijms24065514. MDPI
4. Pretorius E., et al. Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) // Cardiovascular Diabetology. – 2022. – Vol. 21, No. 1. – Art. 148. – DOI: 10.1186/s12933-022-01579-5.














